N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester

Base Information

• Chemical Name: N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester
• CAS No.: 1315314-04-5
• Molecular Formula: C₁₃H₂₁NO₂
• Molecular Weight: 228.276
• Mol file: 1315314-04-5.mol

Synonyms:

Chemical Property of N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester

There total 3 articles about N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(5-hexynyl)-L-alanine methyl ester (873450-75-0) + allyl bromide-d5 (102910-37-2) → N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester (1315314-04-5)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; at 55 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ja2099003

Reference yield:

1-chloro-5-hexyne (10297-06-0) → N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester (1315314-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium iodide / acetone / 48 h / Reflux

2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 70 °C / Inert atmosphere

3.1: tetrabutylammomium bromide; potassium carbonate / tetrahydrofuran / 8 h / 55 °C / Inert atmosphere

With tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; acetone;

DOI:10.1021/ja2099003

Reference yield:

1-iodo-5-hexyne (2468-56-6) → N-(5-hexynyl)-N-allyl-d5-L-alanine methyl ester (1315314-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

1.2: 70 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; potassium carbonate / tetrahydrofuran / 8 h / 55 °C / Inert atmosphere

With tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/ja2099003

upstream raw materials:

N-(5-hexynyl)-L-alanine methyl ester

allyl bromide-d₅

1-chloro-5-hexyne

1-iodo-5-hexyne

Refernces