C₂₉H₂₈F₃N₃O₄

Base Information

Chemical Name:C₂₉H₂₈F₃N₃O₄
CAS No.:1276687-89-8
Molecular Formula:C₂₉H₂₈F₃N₃O₄
Molecular Weight:539.554
Hs Code.:

C<sub>29</sub>H<sub>28</sub>F<sub>3</sub>N<sub>3</sub>O<sub>4</sub>

Synonyms:

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Chemical Property of C₂₉H₂₈F₃N₃O₄

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Technology Process of C₂₉H₂₈F₃N₃O₄

There total 8 articles about C₂₉H₂₈F₃N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276687-85-4
tert-butyl (S)-4-(1-(4-(methoxycarbonyl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)phenyl)-1H-benzo[d]imidazol-5-yloxy)piperidine-1-carboxylate

: 1276687-89-8
C₂₉H₂₈F₃N₃O₄

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-75-2
methyl (S)-4-nitro-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-89-8
C₂₉H₂₈F₃N₃O₄

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

3: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; palladium 10% on activated carbon; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 2: Buchwald-Hartwig reaction / 5: Mitsunobu reaction;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-77-4
methyl (S)-4-amino-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-89-8
C₂₉H₂₈F₃N₃O₄

Guidance literature:: Multi-step reaction with 5 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

2: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

5: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate; 1: Buchwald-Hartwig reaction / 4: Mitsunobu reaction;
DOI:10.1021/jm1011726