allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

Base Information

Chemical Name:allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate
CAS No.:1275617-27-0
Molecular Formula:C₂₈H₄₃BrN₂O₉SSi
Molecular Weight:691.713
Hs Code.:

allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

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Chemical Property of allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

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Technology Process of allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

There total 6 articles about allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₅₇BrN₂O₉SSi

: 1275617-27-0
allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm1014023

Reference yield:

: 1275617-26-9
allyl 2-((R)-2-amino-2-methoxycarbonylethylsulfanylmethyl)-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate

: 1275617-27-0
allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / acetonitrile / 5 h / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; 1,2-dichloro-ethane; In methanol; acetonitrile;
DOI:10.1021/jm1014023

Reference yield:

: 1275616-79-9
(RS)-7-bromo-3,4-dihydroxy-6-methoxy-3H-isobenzofuran-1-one

: 1275617-27-0
allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-6-{(R)-2-[2-(2-hydroxyacetylamino)acetylamino]-2-methoxycarbonylethylsulfanylmethyl}-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

3.2: 2.08 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: 1,2-dichloro-ethane / acetonitrile / 5 h / 0 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; toluene-4-sulfonic acid; 1,2-dichloro-ethane; triethylamine; sodium iodide; N,N,N',N'-tetramethylguanidine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm1014023