(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester

Base Information

• Chemical Name: (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester
• CAS No.: 135912-92-4
• Molecular Formula: C₄₁H₆₅N₃O₁₀
• Molecular Weight: 759.981

Synonyms:

Chemical Property of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester

There total 3 articles about (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Hydroxyhexylazide (124718-84-9) → (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester (135912-92-4,135970-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2 / methanol

2: EDC, HOBt / CH₂Cl₂

3: EDC, DMAP / CH₂Cl₂

With dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(00)91716-7

Reference yield:

1-amino-2-hydroxy-hexane (72799-62-3,208850-64-0,208850-72-0) → (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester (135912-92-4,135970-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: EDC, HOBt / CH₂Cl₂

2: EDC, DMAP / CH₂Cl₂

With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1016/S0040-4039(00)91716-7

Reference yield:

(4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid (121533-54-8) + (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-hexylcarbamoyl)-butyric acid tert-butyl ester (135912-91-3) → (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester (135912-92-4,135970-58-0)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; Yield given;

DOI:10.1016/S0040-4039(00)91716-7

upstream raw materials:

(4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid

(S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-hexylcarbamoyl)-butyric acid tert-butyl ester

1-amino-2-hydroxy-hexane

2-Hydroxyhexylazide

Downstream raw materials:

(S)-2-Benzyl-N-((2S,8S,11S,12R)-2-butyl-11-cyclohexylmethyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

(S)-2-Benzyl-N-((2R,8S,11S,12R)-2-butyl-11-cyclohexylmethyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

[(S)-1-((2S,8S,11S,12R)-2-Butyl-11-cyclohexylmethyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

[(S)-1-((2R,8S,11S,12R)-2-Butyl-11-cyclohexylmethyl-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 135912-92-4 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-pentyl} ester 3-tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send