Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester
CAS No.:126456-38-0
Molecular Formula:C33H40N2O6
Molecular Weight:560.69
Hs Code.:
Mol file:126456-38-0.mol

Carbamic acid,
[(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2-
hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-,
1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester

There total 11 articles about Carbamic acid, [(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2- hydroxy-1-[(4-hydroxyphenyl)methyl]-5-oxo-4-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 126410-52-4
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-<4-(benzyloxy)phenyl>-2(R)-(phenylmethyl)hexanamide

: 126456-38-0
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-(4-hydroxyphenyl)-2(R)-(phenylmethyl)hexanamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 96h;
DOI:10.1021/jm00088a003

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(+/-)-cis-1-amino-indan-2-ol

: 126456-38-0
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-(4-hydroxyphenyl)-2(R)-(phenylmethyl)hexanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h

2: 40 percent / trifluoroacetic acid / CHCl₃ / 2.5 h

3: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating

4: 66 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

6: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 96 h

With 4-methyl-morpholine; sodium hydroxide; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; tetrabutyl ammonium fluoride; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a003

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
trans-1-aminoindan-2-ol

: 126456-38-0
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-(4-hydroxyphenyl)-2(R)-(phenylmethyl)hexanamide

Guidance literature:: Multi-step reaction with 9 steps

1: 20percent aq. NaOH / toluene / 24 h

2: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / aq. H₂SO₄ / H₂O / 16 h / Heating

4: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h

5: 40 percent / trifluoroacetic acid / CHCl₃ / 2.5 h

6: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating

7: 66 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

8: tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

9: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 96 h

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00088a003