Technology Process of Toluene-4-sulfonic acid 2-((2R,4aS)-4a,8-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester
There total 5 articles about Toluene-4-sulfonic acid 2-((2R,4aS)-4a,8-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester which
guide to synthetic route it.
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synthetic route:
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83093-44-1,83093-47-4
Toluene-4-sulfonic acid 2-((2R,4aS)-4a,8-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester
- Guidance literature:
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In
pyridine;
for 16h;
DOI:10.1139/v82-255
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83093-44-1,83093-47-4
Toluene-4-sulfonic acid 2-((2R,4aS)-4a,8-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester
- Guidance literature:
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Multi-step reaction with 5 steps
1: 76 percent / N-bromosuccinimide / tetrahydrofuran; H2O / 22 h / Ambient temperature
2: 71 percent / 2,2-dimethyl-1,3-propanediol, p-toluenesulfonic acid / benzene / 0.17 h / 74 - 79 °C
3: 66 percent / osmium tetroxide / dioxane / 18 h / Ambient temperature
4: 72 percent / potassium hydroxide, 10percent palladium/charcoal, hydrogen / ethanol / 0.5 h / Ambient temperature
5: 86 percent / pyridine / 16 h
With
potassium hydroxide; palladium on activated charcoal; N-Bromosuccinimide; osmium(VIII) oxide; hydrogen; toluene-4-sulfonic acid; 2,2-Dimethyl-1,3-propanediol;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; water; benzene;
DOI:10.1139/v82-255
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-
83093-44-1,83093-47-4
Toluene-4-sulfonic acid 2-((2R,4aS)-4a,8-dimethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / 2,2-dimethyl-1,3-propanediol, p-toluenesulfonic acid / benzene / 0.17 h / 74 - 79 °C
2: 66 percent / osmium tetroxide / dioxane / 18 h / Ambient temperature
3: 72 percent / potassium hydroxide, 10percent palladium/charcoal, hydrogen / ethanol / 0.5 h / Ambient temperature
4: 86 percent / pyridine / 16 h
With
potassium hydroxide; palladium on activated charcoal; osmium(VIII) oxide; hydrogen; toluene-4-sulfonic acid; 2,2-Dimethyl-1,3-propanediol;
In
1,4-dioxane; pyridine; ethanol; benzene;
DOI:10.1139/v82-255