C₄₆H₆₇ClF₃N₃O₉Si

Base Information

Chemical Name:C₄₆H₆₇ClF₃N₃O₉Si
CAS No.:1445598-57-1
Molecular Formula:C₄₆H₆₇ClF₃N₃O₉Si
Molecular Weight:926.586
Hs Code.:

C<sub>46</sub>H<sub>67</sub>ClF<sub>3</sub>N<sub>3</sub>O<sub>9</sub>Si

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Chemical Property of C₄₆H₆₇ClF₃N₃O₉Si

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Technology Process of C₄₆H₆₇ClF₃N₃O₉Si

There total 26 articles about C₄₆H₆₇ClF₃N₃O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: C₃₇H₆₂ClN₃O₇Si

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1445598-57-1
C₄₆H₆₇ClF₃N₃O₉Si

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 23 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ja404578u

Reference yield:

: 960211-04-5
(4S,5S,E)-5,7-di(tert-butyldimethylsilyloxy)-2,4-dimethyl-2-heptenal

: 1445598-57-1
C₄₆H₆₇ClF₃N₃O₉Si

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / ethanol / 25 h / 23 °C / Inert atmosphere

3.1: triethylamine / dichloromethane; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 °C / Inert atmosphere

4.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; water / 6 h / 23 °C / Inert atmosphere

6.1: copper(I) thiophene-2-carboxylate / 1-methyl-pyrrolidin-2-one / 0 - 23 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere

8.1: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

8.2: 0.5 h / 0 °C / Inert atmosphere

9.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 23 °C / Inert atmosphere

10.1: 1H-imidazole / dichloromethane / 18 h / 23 °C / Inert atmosphere

11.1: triethylamine; dmap / dichloromethane / 5 h / 23 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; copper(I) thiophene-2-carboxylate; 18-crown-6 ether; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; 4.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/ja404578u

Reference yield:

: 960211-09-0
(S)-6-((S,3E,5Z)-6-iodo-4-methylhexa-3,5-dien-2-yl)-3-methoxy-5,6-dihydro-2H-pyran-2-one

: 1445598-57-1
C₄₆H₆₇ClF₃N₃O₉Si

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) thiophene-2-carboxylate / 1-methyl-pyrrolidin-2-one / 0 - 23 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere

3.1: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 23 °C / Inert atmosphere

5.1: 1H-imidazole / dichloromethane / 18 h / 23 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 5 h / 23 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; copper(I) thiophene-2-carboxylate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1021/ja404578u