C₁₉H₂₂F₂N₄O₄

Base Information

• Chemical Name: C₁₉H₂₂F₂N₄O₄
• CAS No.: 930100-40-6
• Molecular Formula: C₁₉H₂₂F₂N₄O₄
• Molecular Weight: 408.405
• Mol file: 930100-40-6.mol

Synonyms:

Chemical Property of C₁₉H₂₂F₂N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₂F₂N₄O₄

There total 3 articles about C₁₉H₂₂F₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-nitro-imidazol-1-yl)-acetic acid methyl ester (13230-21-2) → C19H22F2N4O4 (930100-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

2: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.117

Reference yield:

C16H26N4O5 (1309885-38-8) → C19H22F2N4O4 (930100-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / 20 °C

With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2010.12.117

Reference yield:

(4-amino-imidazol-1-yl)-acetic acid methyl ester (688041-31-8) → C19H22F2N4O4 (930100-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane

3: benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / 20 °C

With benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.12.117

upstream raw materials:

C₁₆H₂₆N₄O₅

(4-nitro-imidazol-1-yl)-acetic acid methyl ester

(4-amino-imidazol-1-yl)-acetic acid methyl ester