2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one

Base Information

• Chemical Name: 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one
• CAS No.: 1448899-41-9
• Molecular Formula: C₂₉H₁₉NOS
• Molecular Weight: 429.542
• Mol file: 1448899-41-9.mol

Synonyms:

Chemical Property of 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one

There total 3 articles about 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(diphenylamino)phenylboronic pinacol ester (267221-88-5) + 2-bromo-4H-indeno[1,2-b]thiophen-4-one (1448899-37-3) → 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one (1448899-41-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Aliquat 336; sodium carbonate; In water; for 48h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1002/chem.201301054

Reference yield:

4-N,N-diphenylamino-1-bromobenzene (36809-26-4) → 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one (1448899-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 5.5 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; Aliquat 336 / water / 48 h / Schlenk technique; Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Aliquat 336; sodium carbonate; In tetrahydrofuran; hexane; water; 2.1: |Suzuki Coupling;

DOI:10.1002/chem.201301054

Reference yield:

4H-Indeno<1,2-b>thiophen-4-one (5706-08-1) → 2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4-one (1448899-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Darkness

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; Aliquat 336 / water / 48 h / Schlenk technique; Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Aliquat 336; sodium carbonate; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

DOI:10.1002/chem.201301054

upstream raw materials:

4-(diphenylamino)phenylboronic pinacol ester

2-bromo-4H-indeno[1,2-b]thiophen-4-one

4-N,N-diphenylamino-1-bromobenzene

4H-Indeno<1,2-b>thiophen-4-one

Downstream raw materials:

2-(2-(4-(diphenylamino)phenyl)-4H-indeno[1,2-b]thiophen-4ylidene)malononitrile