Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester
• CAS No.: 661478-40-6
• Molecular Formula: C₂₂H₂₅N₅O₉S
• Molecular Weight: 535.535
• Mol file: 661478-40-6.mol

Synonyms:

Chemical Property of Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

There total 1 articles about Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

toluene-4-sulfonic acid (104-15-4) + C15H17N5O6 (661478-38-2) → Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (661478-40-6) + C37H42N10O15S

Guidance literature:

In chlorobenzene; Heating;

DOI:10.1081/NCN-120022622

Reference yield:

Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (661478-40-6) → Acetic acid 2-{2-acetylamino-9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(toluene-4-sulfonyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6,8-dioxo-1,6,8,9-tetrahydro-purin-7-ylmethoxy}-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 22 h / 48 °C

2: chlorobenzene / 0.5 h / Heating

With triethylamine; In chloroform; chlorobenzene;

DOI:10.1081/NCN-120022622

Reference yield:

Toluene-4-sulfonic acid (3aR,4R,6R,6aR)-6-(2-acetylamino-6,8-dioxo-1,6,7,8-tetrahydro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (661478-40-6) → Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-{2-acetylamino-9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(toluene-4-sulfonyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6,8-dioxo-1,6,8,9-tetrahydro-purin-7-yl}-tetrahydro-furan-3-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 22 h / 48 °C

2: chlorobenzene / 0.5 h / Heating

With triethylamine; In chloroform; chlorobenzene;

DOI:10.1081/NCN-120022622

upstream raw materials:

toluene-4-sulfonic acid

C₁₅H₁₇N₅O₆