Bromo-PEG1-t-butyl ester

Base Information

• Chemical Name: Bromo-PEG1-t-butyl ester
• CAS No.: 1393330-36-3
• Molecular Formula: C₉H₁₇BrO₃
• Molecular Weight: 253.136
• Mol file: 1393330-36-3.mol

Synonyms:

Chemical Property of Bromo-PEG1-t-butyl ester

Chemical Property:

• Boiling Point: 285.0±15.0 °C(Predicted)
• Density: 1.264±0.06 g/cm3(Predicted)
• Solubility.: Soluble in DCM, Hexane

Purity/Quality:

99.3% ^*data from raw suppliers

Bromo-PEG1-t-butylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromo-PEG1-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of Bromo-PEG1-t-butyl ester

There total 1 articles about Bromo-PEG1-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.8%

3-(2-hydroxyethoxy)propionic acid tert-butyl ester (671802-00-9,892154-71-1) → tert-butyl 3-(2-bromoethoxy)propanoate (1393330-36-3)

Guidance literature:

3-(2-hydroxyethoxy)propionic acid tert-butyl ester; With carbon tetrabromide; In dichloromethane; at 0 ℃;

With triphenylphosphine; In dichloromethane; for 0.5h;

Reference yield: 95.0%

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + tert-butyl 3-(2-bromoethoxy)propanoate (1393330-36-3) + trifluoroacetic acid (76-05-1) → (x)C2HF3O2*C21H32N2O5

Guidance literature:

phenylmethyl 1-piperazinecarboxylate; tert-butyl 3-(2-bromoethoxy)propanoate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 75 ℃;

trifluoroacetic acid;

Reference yield:

(2S,4R)-1-[(2S)-2-[(1-fluorocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl] -4-hydroxy-N-[[2-hydroxy-4-(4-methylthiazol-5- yl) phenyl] methyl]pyrrolidine-2-carboxamide + tert-butyl 3-(2-bromoethoxy)propanoate (1393330-36-3) → tert-butyl 3-{2-[2-({[(2S,4R)-1-[(2S)-2-[(1- fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2- yl]formamido}methyl)-5-(4-methyl-1,3-thiazol-5-yl)phenoxy]ethoxy}propanoate

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

3-(2-hydroxyethoxy)propionic acid tert-butyl ester

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