5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Base Information

Chemical Name:5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt
CAS No.:1610736-91-8
Molecular Formula:C₂HF₃O₂*C₃₅H₃₆FN₅O₆
Molecular Weight:755.723
Hs Code.:

5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Synonyms:

Suppliers and Price of 5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

There total 8 articles about 5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 27828-71-3
5-hydroxynicotinic acid

: N-((1s,4s)-4-aminocyclohexyl)-5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamide dihydrochloride

: 76-05-1
trifluoroacetic acid

: 1610736-91-8
5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Guidance literature:: 5-hydroxynicotinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 18 - 25 ℃; for 0.166667h; Inert atmosphere;

N-((1s,4s)-4-aminocyclohexyl)-5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamide dihydrochloride; With 1-methyl-pyrrolidin-2-one; In acetonitrile; at 18 - 25 ℃; for 20h; Inert atmosphere;

trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jm5001216

Reference yield:

: 1197291-03-4
tert-butyl (1s,4s)-4-(5-fluoro-2-(2'-formyl-4'-hydroxybiphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

: 1610736-91-8
5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane; methanol / 0.83 h / 18 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 18 - 25 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 0.17 h / 18 - 25 °C / Inert atmosphere

3.2: 20 h / 18 - 25 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm5001216

Reference yield:

: 1197291-00-1
tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

: 1610736-91-8
5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 16 h / 18 - 25 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 0.17 h / 18 - 25 °C / Inert atmosphere

2.2: 20 h / 18 - 25 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm5001216