2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

Base Information

Chemical Name:2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide
CAS No.:1395074-23-3
Molecular Formula:C₂₂H₂₀ClF₂N₅O₂
Molecular Weight:459.883
Hs Code.:

2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

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Chemical Property of 2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

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Technology Process of 2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

There total 5 articles about 2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496856-52-1,933786-63-1
(S)-2-amino-2-(3-chloro-4-fluorophenyl)ethan-1-ol

: 1395079-42-1
C₁₃H₁₃FN₄

: 530-62-1
1,1'-carbonyldiimidazole

: 1395074-23-3
2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

Guidance literature:: (S)-2-amino-2-(3-chloro-4-fluorophenyl)ethan-1-ol; 1,1'-carbonyldiimidazole; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

C₁₃H₁₃FN₄; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.04.068 DOI:10.1016/j.bmcl.2014.04.068

Reference yield:

: C₁₈H₂₁FN₄O₂

: 1395074-23-3
2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; 1,4-dioxane; dichloromethane; methanol / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

2.2: 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2014.04.068

Reference yield:

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 1395074-23-3
2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 16 h / 20 °C

2.1: sodium ethanolate / ethanol / 18 h / 45 °C

3.1: hydrogenchloride / water; 1,4-dioxane; dichloromethane; methanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

4.2: 2 h / 20 °C

With hydrogenchloride; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2014.04.068