allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

Base Information

Chemical Name:allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate
CAS No.:1275617-30-5
Molecular Formula:C₂₉H₄₃BrN₄O₇SSi
Molecular Weight:699.739
Hs Code.:

allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

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Chemical Property of allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

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Technology Process of allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

There total 8 articles about allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₅₁BrN₄O₉SSi

: 1275617-30-5
allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm1014023

Reference yield:

: 1275616-79-9
(RS)-7-bromo-3,4-dihydroxy-6-methoxy-3H-isobenzofuran-1-one

: 1275617-30-5
allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

3.2: 2.08 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / 0.5 h / 0 °C / Inert atmosphere

With chloro-trimethyl-silane; triethylamine; trifluoroacetic acid; sodium iodide; N,N,N',N'-tetramethylguanidine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm1014023

Reference yield:

: 1275616-78-8
(RS)-3,4-dihydroxy-6-methoxy-3H-isobenzofuran-1-one

: 1275617-30-5
allyl 2-[(R)-2-amino-2-(3-allyloxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-[dimethyl(thexyl)silyloxy]-6-bromo-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / dichloromethane / 2.18 h / 0 - 20 °C / Inert atmosphere

2.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

4.2: 2.08 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / 0.5 h / 0 °C / Inert atmosphere

With chloro-trimethyl-silane; bromine; triethylamine; trifluoroacetic acid; sodium iodide; N,N,N',N'-tetramethylguanidine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm1014023