(8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

Base Information

Chemical Name:(8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)
CAS No.:1274848-46-2
Molecular Formula:C₁₉H₁₇NO
Molecular Weight:275.35
Hs Code.:

Synonyms:

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Chemical Property of (8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

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Technology Process of (8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

There total 5 articles about (8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1274848-15-5
8-iodo-6-methyl-2,3-dihydroquinolin-4(1H)-one

: 1274848-46-2
(8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: palladium dichloride / acetonitrile / 4 h / 70 - 80 °C

With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; palladium dichloride; In ethanol; acetonitrile; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1274848-46-2
(8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 4 h / 70 °C

2.1: methanesulfonic acid; phosphorus pentoxide / 12 h / 90 °C

3.1: Iodine monochloride; calcium carbonate / methanol; water / 2 h / 0 - 20 °C

4.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere

4.2: 2 h / 80 °C / Inert atmosphere

5.1: palladium dichloride / acetonitrile / 4 h / 70 - 80 °C

With copper(l) iodide; methanesulfonic acid; phosphorus pentoxide; palladium 10% on activated carbon; Iodine monochloride; acetic acid; triethylamine; triphenylphosphine; calcium carbonate; palladium dichloride; In methanol; ethanol; water; acetonitrile; 4.1: Sonogashira coupling / 4.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d

Reference yield:

: 21911-85-3
methyl 3-(p-toluidino)propanoate

: 1274848-46-2
(8-methyl-5-p-tolyl-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one)

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid; phosphorus pentoxide / 12 h / 90 °C

2.1: Iodine monochloride; calcium carbonate / methanol; water / 2 h / 0 - 20 °C

3.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere

3.2: 2 h / 80 °C / Inert atmosphere

4.1: palladium dichloride / acetonitrile / 4 h / 70 - 80 °C

With copper(l) iodide; methanesulfonic acid; phosphorus pentoxide; palladium 10% on activated carbon; Iodine monochloride; triethylamine; triphenylphosphine; calcium carbonate; palladium dichloride; In methanol; ethanol; water; acetonitrile; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d