Technology Process of 2-[2,6-dimethyl-4-({[(5-methyl-1,3,4-oxadiazol-2-yl) methyl]-({5-methyl-2-[4-(trifluoromethoxy) phenyl]-1,3-oxazol-4-yl}-methyl) amino}methyl) phenoxy]-2-methylpropanoic acid hydrochloride
There total 9 articles about 2-[2,6-dimethyl-4-({[(5-methyl-1,3,4-oxadiazol-2-yl) methyl]-({5-methyl-2-[4-(trifluoromethoxy) phenyl]-1,3-oxazol-4-yl}-methyl) amino}methyl) phenoxy]-2-methylpropanoic acid hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C31H35F3N4O6;
With
water; sodium hydroxide;
In
methanol;
at 20 ℃;
Reflux;
With
hydrogenchloride;
In
1,4-dioxane;
DOI:10.1248/cpb.c13-00513
- Guidance literature:
-
Multi-step reaction with 9 steps
1: magnesium sulfate / tetrahydrofuran / 4 h / Reflux
2: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C
3: acetonitrile / 4 h / 0 - 20 °C
4: trifluoroacetic acid / dichloromethane / 0 - 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C
6: hexachloroethane; triethylamine; triphenylphosphine / dichloromethane / 20 °C
7: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 0 °C
8: caesium carbonate; potassium iodide / acetonitrile / 75 °C
9: sodium hydroxide; water / methanol / 20 °C / Reflux
With
sodium tetrahydroborate; hexachloroethane; water; magnesium sulfate; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C
2: acetonitrile / 4 h / 0 - 20 °C
3: trifluoroacetic acid / dichloromethane / 0 - 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C
5: hexachloroethane; triethylamine; triphenylphosphine / dichloromethane / 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 0 °C
7: caesium carbonate; potassium iodide / acetonitrile / 75 °C
8: sodium hydroxide; water / methanol / 20 °C / Reflux
With
sodium tetrahydroborate; hexachloroethane; water; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513
