di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate

Base Information

• Chemical Name: di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate
• CAS No.: 1612254-94-0
• Molecular Formula: C₅₀H₇₂N₈O₁₁
• Molecular Weight: 961.169
• Mol file: 1612254-94-0.mol

Synonyms:

Chemical Property of di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate

There total 1 articles about di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[(2-((1R,2S,6R,7S)-3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)ethyl)(ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate → di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate (1612254-94-0)

Guidance literature:

In toluene; for 5h; Reflux;

DOI:10.1021/ja5026326

Reference yield:

di(tert-butyl) (2R,4S)-2-{4-[((1S)-5-(acetylamino)-1-{[4-((E)-{4-[[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl](ethyl)amino]phenyl}-1-diazenyl)anilino]carbonyl}pentyl)amino]-4-oxobutyl}-4-[(tertbutoxycarbonyl)amino]pentane-1,5-dioate (1612254-94-0) → C37H48N8O9*C2HF3O2

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 5 h / 20 °C

2: dimethylsulfoxide-d6 / Irradiation

In dimethylsulfoxide-d6; dichloromethane;

DOI:10.1021/ja5026326