N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride

Base Information

• Chemical Name: N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride
• CAS No.: 1322717-46-3
• Molecular Formula: C₃₂H₃₆N₃O₂*Cl
• Molecular Weight: 530.11
• Mol file: 1322717-46-3.mol

Synonyms:

Chemical Property of N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride

There total 2 articles about N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl(propargyl)amine (35161-71-8) + rhodamine B (81-88-9) → N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride (1322717-46-3,1360565-03-2)

Guidance literature:

rhodamine B; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 1h;

methyl(propargyl)amine; With sodium carbonate; In dichloromethane; at 20 ℃; for 18h; Time;

Reference yield:

rhodamine B (81-88-9) → N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride (1322717-46-3,1360565-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: sodium carbonate / dichloromethane / 18 h / 20 °C

With oxalyl dichloride; sodium carbonate; In dichloromethane;

DOI:10.1002/anie.201102072

Reference yield: 92.0%

2,5-dioxopyrrolidin-1-yl 4-(azidomethyl)benzoate (916687-71-3) + N-(6-(diethylamino)-9-(2-(methyl(prop-2-yn-1-yl)carbamoyl)phenyl)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride (1322717-46-3,1360565-03-2) → N-methyl N-[5-iodo-1-(4-methyl-N-succinimidyl benzoate)-4-methyl-1,2,3-thiazole]rhodamine B carboxamide (1322717-47-4)

Guidance literature:

With N-iodo-succinimide; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201102072

upstream raw materials:

rhodamine B

methyl(propargyl)amine

Downstream raw materials:

N-methyl N-[5-iodo-1-(4-methyl-N-succinimidyl benzoate)-4-methyl-1,2,3-thiazole]rhodamine B carboxamide

N-methyl N-[5-[¹²⁵I]iodo-1-(4-methyl-N-succinimidyl benzoate)-4-methyl-1,2,3-thiazole]rhodamine B carboxamide

N-(1-benzyl-5-iodo-1H-[1,2,3]triazol-4-yl)methyl-N-methylrhodaminamide

N-(1-benzyl-5-[¹²⁵I]iodo-1H-[1,2,3]triazol-4-yl)methyl-N-methylrhodaminamide