4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester
CAS No.:194031-45-3
Molecular Formula:C₃₅H₃₆N₂O₁₀
Molecular Weight:644.678
Hs Code.:

4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

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Chemical Property of 4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

There total 4 articles about 4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 194031-43-1
4-Oxo-pentanoic acid (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

: 194031-45-3
4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Guidance literature:: With pyridine; silver nitrate; for 24h; Ambient temperature;

Reference yield:

: 40608-06-8
levulinic anhydride

: 194031-45-3
4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / pyridine, DMAP / diethyl ether / 1.5 h

2: 76 percent / TBAF / tetrahydrofuran / 0.25 h

3: 96 percent / pyridine, AgNO₃ / 24 h / Ambient temperature

With pyridine; dmap; tetrabutyl ammonium fluoride; silver nitrate; In tetrahydrofuran; diethyl ether;

Reference yield:

: 104477-70-5
5',3'-O-(tetraisopropyldisiloxane-1,3-di-yl)-1-β-D-arabinofuranosyl-uracil

: 194031-45-3
4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / pyridine, DMAP / diethyl ether / 1.5 h

2: 76 percent / TBAF / tetrahydrofuran / 0.25 h

3: 96 percent / pyridine, AgNO₃ / 24 h / Ambient temperature

With pyridine; dmap; tetrabutyl ammonium fluoride; silver nitrate; In tetrahydrofuran; diethyl ether;