1H-Imidazole-1-carboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Imidazole-1-carboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester
• CAS No.: 127119-12-4
• Molecular Formula: C15H25N3O4
• Molecular Weight: 311.37700
• Mol file: 127119-12-4.mol

Synonyms:tert-butyl 4-(2-(tert-butoxycarbonylamino)ethyl)-1H-imidazole-1-carboxylate;N,N'-DI(TERT-BUTOXYCARBONYL)-HISTAMINE, SYNTHETIC;N,1-bis(t-butoxycarbonyl)histamine;4-(2-tert-butoxycarbonylaminoethyl)imidazole-1-carboxylic acid tert-butyl ester;1-t-Butoxycarbonyl-4-[2-(t-butoxycarbonylamino)ethyl]imidazole;

Chemical Property of 1H-Imidazole-1-carboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 82.45000
• LogP: 3.12440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-1-carboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester

There total 2 articles about 1H-Imidazole-1-carboxylic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + histamine dichloride (56-92-8) → N,1-bis(t-butoxycarbonyl)histamine (127119-12-4)

Guidance literature:

histamine dichloride; With triethylamine; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.8b02612

Reference yield: 38.0%

di-tert-butyl dicarbonate (24424-99-5) + histamine (51-45-6) → N,1-bis(t-butoxycarbonyl)histamine (127119-12-4)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmcl.2011.06.030

Reference yield: 94.0%

N,1-bis(t-butoxycarbonyl)histamine (127119-12-4) → Nα-(tert-butoxycarbonyl)histamine (98870-64-5)

Guidance literature:

With silica gel; In dichloromethane; at 50 ℃; for 10h; under 0.2 Torr;

DOI:10.1016/0040-4039(95)02398-4

upstream raw materials:

di-tert-butyl dicarbonate

histamine

histamine dichloride

Downstream raw materials:

N^α-(tert-butoxycarbonyl)histamine

Refernces

• 1、 Saada, Mohamed-Chiheb,Vullo, Daniela,Montero, Jean-Louis,Scozzafava, Andrea,Winum, Jean-Yves,Supuran, Claudiu T.. "Carbonic anhydrase i and II activation with mono- and dihalogenated histamine derivatives". . p. 4884 - 4887. Retrieved 2011.
• 2、 -. "ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS". Page/Page column 65; Sheet 12. . Retrieved 2010/02/11.