2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

Base Information

Chemical Name:2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide
CAS No.:1258459-27-6
Molecular Formula:C₁₀H₁₃NO₂S₂
Molecular Weight:243.351
Hs Code.:

Synonyms:

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Chemical Property of 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

Chemical Property:

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Technology Process of 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

There total 5 articles about 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-04-9
[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-acetonitrile

: 1258459-27-6
2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

Guidance literature:: [5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-acetonitrile; With hexamethyldisilathiane; sodium methylate; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

In N,N-dimethyl-formamide;

Reference yield:

: 5916-12-1
2-methyl-2-(thiophen-2-yl)-[1,3]dioxolane

: 1258459-27-6
2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / 1.08 h / 0 - 20 °C / Inert atmosphere

3.1: dmap; triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

5.1: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With methanol; dmap; sodium tetrahydroborate; n-butyllithium; hexamethyldisilathiane; N,N,N,N,-tetramethylethylenediamine; sodium methylate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 524071-59-8
[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-methanol

: 1258459-27-6
2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-yl]-thioacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

3: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With dmap; hexamethyldisilathiane; sodium methylate; methanesulfonyl chloride; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;