Technology Process of N-[(3β,5α)-20-oxopregnan-3-yl]benzenesulfonamide
There total 6 articles about N-[(3β,5α)-20-oxopregnan-3-yl]benzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Dess-Martin periodane / dichloromethane / 20 h / 20 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 5 - 20 °C / Inert atmosphere
3.2: 16 h / 9 - 20 °C / Inert atmosphere
4.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux
5.1: triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / dichloromethane; water; acetone / 72 h
With
hydrogenchloride; potassium tri-sec-butyl-borohydride; Dess-Martin periodane; hydrazine hydrate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm300317k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / tetrahydrofuran / 5 - 20 °C / Inert atmosphere
1.2: 16 h / 9 - 20 °C / Inert atmosphere
2.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux
3.1: triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / dichloromethane; water; acetone / 72 h
With
hydrogenchloride; hydrazine hydrate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm300317k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere
3: hydrogenchloride / dichloromethane; water; acetone / 72 h
With
hydrogenchloride; hydrazine hydrate; triethylamine;
In
ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm300317k