(R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

Base Information

Chemical Name:(R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate
CAS No.:1580522-25-3
Molecular Formula:C₁₄H₁₆O₃
Molecular Weight:232.279
Hs Code.:

Synonyms:

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Chemical Property of (R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

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Technology Process of (R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

There total 2 articles about (R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₄O₃

: 1580522-25-3
(R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

Guidance literature:: With Noyori's catalyst; potassium hydroxide; In isopropyl alcohol; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201309162

Reference yield:

: 67654-83-5
4-oxo-4-(2-phenylethynyl)-1-butanol

: 1580522-25-3
(R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

2: Noyori's catalyst; potassium hydroxide / isopropyl alcohol / 16 h / 20 °C / Inert atmosphere

With pyridine; dmap; Noyori's catalyst; potassium hydroxide; In dichloromethane; isopropyl alcohol;
DOI:10.1002/anie.201309162

Reference yield:

: 1580522-25-3
(R)-4-hydroxy-6-phenylhex-5-yn-1-yl acetate

: 1580522-23-1
(R)-methyl (6-(4-methylphenylsulfonamido)-1-phenylhex-1-yn-3-yl)carbonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole; dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4: methyllithium / diethyl ether / 0.17 h / -20 °C / Inert atmosphere

5: (1S)-10-camphorsulfonic acid / methanol / 2 h / 20 °C / Inert atmosphere

6: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; di-isopropyl azodicarboxylate; (1S)-10-camphorsulfonic acid; methyllithium; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1002/anie.201309162