4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

Base Information

Chemical Name:4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate
CAS No.:238748-84-0
Molecular Formula:C₂₇H₃₆N₄O₇S
Molecular Weight:560.671
Hs Code.:

4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2-<methyl(phenyl)amino>-2-thioxoethyl>amino>carbonyl>butyl>carbamate

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Chemical Property of 4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

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Technology Process of 4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

There total 4 articles about 4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1016-58-6
6-nitroveratryl alcohol

: 238748-84-0
4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / toluene; tetrahydrofuran / 4 h / 0 °C

2: 67 percent / NaOH / H₂O; tetrahydrofuran; dioxane / 0 deg C to rt; rt, 27 h

3: 1.) isobutyl chloroformate, N-methylmorpholine, 2.) H₂S / 1.) THF, -10 deg C, 5 min, 2.) THF, -10 deg C, 1 h

4: CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen sulfide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5

Reference yield:

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 238748-84-0
4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaOH / H₂O; tetrahydrofuran; dioxane / 0 deg C to rt; rt, 27 h

2: 1.) isobutyl chloroformate, N-methylmorpholine, 2.) H₂S / 1.) THF, -10 deg C, 5 min, 2.) THF, -10 deg C, 1 h

3: CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen sulfide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5

Reference yield:

: 217176-96-0
N-<(4,5-dimethoxy-2-nitrobenzyloxy)carbonyl>-L-isoleucine

: 238748-84-0
4,5-dimethoxy-2-nitrobenzyl N-<(1S,2S)-2-methyl-1-<<<1,1-dimethyl-2--2-thioxoethyl>amino>carbonyl>butyl>carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine, 2.) H₂S / 1.) THF, -10 deg C, 5 min, 2.) THF, -10 deg C, 1 h

2: CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; hydrogen sulfide; isobutyl chloroformate; In dichloromethane;
DOI:10.1002/(SICI)1522-2675(19990609)82:6<888::AID-HLCA888>3.0.CO;2-5