(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

Base Information

Chemical Name:(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid
CAS No.:1268617-82-8
Molecular Formula:C₃₂H₃₅N₇O₆S₂
Molecular Weight:677.805
Hs Code.:

(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

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Chemical Property of (S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

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Technology Process of (S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

There total 9 articles about (S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1268617-82-8
(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

Guidance literature:

Reference yield:

: Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-N2-(3-((5-(2-(((pyridin-2-ylmethyl)amino)methyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine

: 1268617-82-8
(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.8b00210

Reference yield:

: 1268618-44-5
(S)-2-{[3-(5-bromo-2,3-dihydrobenzofuran-7-sulfonylamino)thiophene-2-carbonyl]amino}-5-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonylguanidino)pentanoic acid methyl ester

: 1268617-82-8
(S)-5-guanidino-2-({3-[5-(2-{[(pyridin-2-ylmethyl)-amino]-methyl}-phenyl)-2,3-dihydro-benzofuran-7-sulfonylamino]-thiophene-2-carbonyl}-amino)-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; water / 3 h / 20 °C / Alkaline conditions

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 0.17 h / 90 °C / Inert atmosphere; Microwave irradiation

3.1: acetic acid / tetrahydrofuran; methanol / 2 h / 20 °C / pH Ca_. 6

3.2: 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.8b00210