(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Base Information

Chemical Name:(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one
CAS No.:1422128-04-8
Molecular Formula:C₂₃H₂₁F₆N₃OS
Molecular Weight:501.496
Hs Code.:

(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

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Chemical Property of (5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

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Technology Process of (5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

There total 4 articles about (5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422129-05-2
4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

: 1422129-59-6
(3aR,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrole-5-carbaldehyde

: (5Z)-5-({(3aR,5S,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

: 1422128-04-8
(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: With piperdinium acetate; In isopropyl alcohol; at 70 ℃; for 3h; Catalytic behavior;

Reference yield:

: 1422238-19-4
(3aR,6aS)-octahydrocyclopenta[c]pyrrol-5-ylmethanol hydrochloride

: 1422128-04-8
(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 0 - 20 °C

3: piperdinium acetate / isopropyl alcohol / 3 h / 70 °C

With sulfur trioxide pyridine complex; piperdinium acetate; potassium carbonate; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 650578-12-4
tert-butyl (3aR,6aS)-5-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole2-carboxylate

: 1422128-04-8
(5Z)-5-({(3aR,5r,6aS)-2-[2,4-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-5-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 0 - 20 °C

4: piperdinium acetate / isopropyl alcohol / 3 h / 70 °C

With hydrogenchloride; sulfur trioxide pyridine complex; piperdinium acetate; potassium carbonate; dimethyl sulfoxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;