N-(benzyloxycarbonyl)-L-asparaginamide

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-L-asparaginamide
• CAS No.: 93185-73-0
• Molecular Formula: C₁₂H₁₅N₃O₄
• Molecular Weight: 265.269
• Mol file: 93185-73-0.mol

Synonyms:

Chemical Property of N-(benzyloxycarbonyl)-L-asparaginamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)-L-asparaginamide

There total 7 articles about N-(benzyloxycarbonyl)-L-asparaginamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Z-Asn-Ser-OMe (2575-86-2) → N-(benzyloxycarbonyl)-L-asparaginamide (93185-73-0,962-51-6)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; for 1.5h; Ambient temperature; pH 3;

DOI:10.1021/ja00094a008

Reference yield:

C12H14N2O5*H3N → N-(benzyloxycarbonyl)-L-asparaginamide (93185-73-0,962-51-6)

Guidance literature:

With Bacillus licheniformis serine endoprotease; ammonia; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetlet.2012.05.039

Reference yield:

N-benzyloxycarbonyl-L-asparagine (2304-96-3) → N-(benzyloxycarbonyl)-L-asparaginamide (93185-73-0,962-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 20 °C

2: NH₃ (gas) / dimethylformamide / 20 °C

With ammonia; In N,N-dimethyl-formamide;

DOI:10.1007/BF02219454

upstream raw materials:

3-(S)-N-benzyloxycarbonylaminopyrrolidine-2,5-dione

N-benzyloxycarbonyl-L-asparagine p-nitrophenyl ester

Z-Asn-Ser-OMe

N-benzyloxycarbonyl-L-asparagine

Downstream raw materials:

L-asparagine amide