2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid

Base Information

• Chemical Name: 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid
• CAS No.: 1571212-14-0
• Molecular Formula: C₂₃H₂₄BrFN₄O₅S
• Molecular Weight: 567.436
• Mol file: 1571212-14-0.mol

Synonyms:

Chemical Property of 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid

There total 4 articles about 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydro-pyrimidine-5-carboxylate (1092953-04-2) + 2-(morpholin-3-yl)acetic acid (86236-84-2,1257848-43-3,1257856-13-5) → 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid (1571212-14-0)

Guidance literature:

With potassium carbonate; In ethanol; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01914

Reference yield:

(S)-1-isopropoxy-1-oxopropan-2-yl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate → 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid (1571212-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium / 1.5 h / 43 - 78 °C / Inert atmosphere

2: N-Bromosuccinimide / tetrachloromethane / 70 °C

3: potassium carbonate / ethanol / 25 °C / Inert atmosphere

With N-Bromosuccinimide; lithium; potassium carbonate; In tetrachloromethane; ethanol;

DOI:10.1021/acs.jmedchem.7b01914

Reference yield:

ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1092952-98-1,1345097-86-0) → 2-(4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-3-yl)acetic acid (1571212-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrachloromethane / 70 °C

2: potassium carbonate / ethanol / 25 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; In tetrachloromethane; ethanol;

DOI:10.1021/acs.jmedchem.7b01914

upstream raw materials:

ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydro-pyrimidine-5-carboxylate

2-(morpholin-3-yl)acetic acid

ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate