Technology Process of 3-benzyl-5-(2-(sec-butyl)-4-(5-(naphthalen-2-ylmethyl)pyridin-3-yl)phenyl)pyridine
There total 10 articles about 3-benzyl-5-(2-(sec-butyl)-4-(5-(naphthalen-2-ylmethyl)pyridin-3-yl)phenyl)pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate;
In
1,2-dimethoxyethane;
at 80 ℃;
DOI:10.1002/chem.201203006
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 120 °C / Schlenk technique
2.1: TurboGrignard / tetrahydrofuran / 1.5 h / -78 °C
2.2: -78 - 20 °C
3.1: thionyl chloride / 1.5 h / -12 - 20 °C
4.1: TurboGrignard / tetrahydrofuran / 1.5 h / -78 °C
4.2: -78 - 20 °C
5.1: acetic acid; zinc / dichloromethane / 2 h / 20 °C
6.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane / 80 °C
With
copper(l) iodide; TurboGrignard; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; acetic acid; sodium iodide; N,N`-dimethylethylenediamine; zinc;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;
6.1: |Suzuki Coupling;
DOI:10.1002/chem.201203006
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: TurboGrignard / tetrahydrofuran / 1.5 h / -78 °C
1.2: -78 - 20 °C
2.1: thionyl chloride / 1.5 h / -12 - 20 °C
3.1: TurboGrignard / tetrahydrofuran / 1.5 h / -78 °C
3.2: -78 - 20 °C
4.1: acetic acid; zinc / dichloromethane / 2 h / 20 °C
5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane / 80 °C
With
TurboGrignard; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; acetic acid; zinc;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
5.1: |Suzuki Coupling;
DOI:10.1002/chem.201203006