(R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

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Chemical Name:(R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide
CAS No.:1589540-98-6
Molecular Formula:C₁₉H₂₁FN₆O₂
Molecular Weight:384.413
Hs Code.:

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Chemical Property of (R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

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Technology Process of (R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

There total 4 articles about (R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1589540-98-6
(R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: rac-Pro-OH; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 24 h / 70 °C

2.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate / tetrahydrofuran / 6 h / 20 - 50 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

3.2: 1 h / 20 °C

3.3: 0.25 h

4.1: selectfluor / methanol; N,N-dimethyl acetamide / 20 - 55 °C

With copper(l) iodide; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); selectfluor; potassium carbonate; N-ethyl-N,N-diisopropylamine; rac-Pro-OH; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 1589540-87-3
(R)-1-(3-(ethylamino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea

: 1589540-98-6
(R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

1.2: 1 h / 20 °C

1.3: 0.25 h

2.1: selectfluor / methanol; N,N-dimethyl acetamide / 20 - 55 °C

With selectfluor; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 1589540-86-2
6-chloro-N-ethyl-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-amine

: 1589540-98-6
(R)-N-ethyl-N-(7-fluoro-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate / tetrahydrofuran / 6 h / 20 - 50 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

2.2: 1 h / 20 °C

2.3: 0.25 h

3.1: selectfluor / methanol; N,N-dimethyl acetamide / 20 - 55 °C

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); selectfluor; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;