3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Base Information

• Chemical Name: 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride
• CAS No.: 1259026-96-4
• Molecular Formula: C₂₂H₁₉F₄N₃O*ClH
• Molecular Weight: 453.867
• Mol file: 1259026-96-4.mol

Synonyms:

Chemical Property of 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride

There total 8 articles about 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene (1221349-79-6) → 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride (1259026-96-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethyl acetate;

DOI:10.1021/jm101075v

Reference yield:

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester (1015770-74-7) → 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride (1259026-96-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

4.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1021/jm101075v

Reference yield:

2'-fluoro-3-nitro-5-(trifluoromethyl)-[1,1'-biphenyl]-4-amine (1259026-60-2) → 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride (1259026-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; iron / ethanol; water / 4 h / 80 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

2.2: 3 h / 100 °C

3.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; iron; triethylamine; In diethyl ether; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/jm101075v

upstream raw materials:

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride

3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

2'-fluoro-3-nitro-5-(trifluoromethyl)-[1,1'-biphenyl]-4-amine