Technology Process of 17,18-Seco-7-O-acetyl-18,18O-didehydro-17-desoxo-17-(cytochalasin-D)saeure
There total 7 articles about 17,18-Seco-7-O-acetyl-18,18O-didehydro-17-desoxo-17-(cytochalasin-D)saeure which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
jones reagent;
In
water; acetone;
at 0 ℃;
for 0.25h;
Yield given;
DOI:10.1002/hlca.19820650210
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / NaBH4 / dioxane; H2O / 2 h / Ambient temperature
2: 70 percent / p-toluenesulfonic acid / 2 h / Ambient temperature
3: 86 percent / pyridine / 24 h / Ambient temperature
4: 2.) Jones reagent / 1.) 80percent AcOH, 45 deg C, 12 h; 2.) H2O, 0 deg C, 30 min
5: 55 percent / NaBH4 / dioxane; H2O / 2 h / Ambient temperature
6: 60 percent / HIO4 / dioxane; H2O / 1.5 h / Ambient temperature
7: Jones reagent / acetone; H2O / 0.25 h / 0 °C
With
sodium tetrahydroborate; jones reagent; toluene-4-sulfonic acid; periodic acid;
In
1,4-dioxane; pyridine; water; acetone;
DOI:10.1002/hlca.19820650210
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / p-toluenesulfonic acid / 2 h / Ambient temperature
2: 86 percent / pyridine / 24 h / Ambient temperature
3: 2.) Jones reagent / 1.) 80percent AcOH, 45 deg C, 12 h; 2.) H2O, 0 deg C, 30 min
4: 55 percent / NaBH4 / dioxane; H2O / 2 h / Ambient temperature
5: 60 percent / HIO4 / dioxane; H2O / 1.5 h / Ambient temperature
6: Jones reagent / acetone; H2O / 0.25 h / 0 °C
With
sodium tetrahydroborate; jones reagent; toluene-4-sulfonic acid; periodic acid;
In
1,4-dioxane; pyridine; water; acetone;
DOI:10.1002/hlca.19820650210
