3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid

Base Information

• Chemical Name: 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid
• CAS No.: 1002328-44-0
• Molecular Formula: C₁₁H₉F₃N₂O₂
• Molecular Weight: 258.2
• Mol file: 1002328-44-0.mol

Synonyms:

Chemical Property of 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid

There total 2 articles about 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propan-1-ol (1002328-50-8) → 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid (1002328-44-0)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; water; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200901385

Reference yield: 77.0%

3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)acrylic acid → 3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid (1002328-44-0)

Guidance literature:

With hydrogen; Wilkinson's catalyst; In methanol; at 20 ℃; for 10h;

DOI:10.1248/cpb.55.1540

Reference yield:

3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid (1002328-44-0) → C11H8ClF3N2O

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200901385

upstream raw materials:

3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propan-1-ol

Refernces

• 1、 Hashimoto, Makoto,Kato, Yuh-Hi,Hatanaka, Yasumaru. "Selective hydrogenation of alkene in (3-trifluoromethyl) phenyldiazirine photophor with Wilkinson's catalyst for photoaffinity labeling". . p. 1540 - 1543. Retrieved 2008/03/11.