2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 956593-48-9
• Molecular Formula: C₂₉H₃₄N₂OS
• Molecular Weight: 458.668
• Mol file: 956593-48-9.mol

Synonyms:

Chemical Property of 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-48-9) + 2-methyl-4-(4-(methylsulfanyl)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-61-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.1: caesium carbonate / copper(l) iodide / 1-Methylpyrrolidine / 4 h / 195 °C / Microwave irradiation

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium tetrahydroborate / methanol; water / 3.5 h / 0 °C

4.2: 1 h

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h

6.1: sodium tetrahydroborate / ethanol / 1 h

7.1: methylsulfinic acid / dichloromethane / 18 h

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; methylsulfinic acid; In tetrahydrofuran; 1-Methylpyrrolidine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-methylsulfanyl-phenyl)-ethan-1-one (1086400-86-3) → 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-48-9) + 2-methyl-4-(4-(methylsulfanyl)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 1 h

2: methylsulfinic acid / dichloromethane / 18 h

With sodium tetrahydroborate; methylsulfinic acid; In ethanol; dichloromethane;

Reference yield:

piperidine (110-89-4) → 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-48-9) + 2-methyl-4-(4-(methylsulfanyl)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline (956593-61-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.1: caesium carbonate / copper(l) iodide / 1-Methylpyrrolidine / 4 h / 195 °C / Microwave irradiation

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium tetrahydroborate / methanol; water / 3.5 h / 0 °C

4.2: 1 h

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h

6.1: sodium tetrahydroborate / ethanol / 1 h

7.1: methylsulfinic acid / dichloromethane / 18 h

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; methylsulfinic acid; In tetrahydrofuran; 1-Methylpyrrolidine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

2-methyl-4-(4-methylsulfanyl-phenyl)-1,2,3,4-tetrahydro-isoquinolin-7-ol

1-(3-bromobenzyl)piperidine

piperidine

m-bromobenzoic aldehyde

Downstream raw materials:

2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline trifluoroacetic acid salt

2-methyl-4-(4-(methylsulfanyl)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline trifluoroacetic acid salt