(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

Base Information

Chemical Name:(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one
CAS No.:110815-20-8
Molecular Formula:C₅₅H₇₄O₈S₂Si
Molecular Weight:955.405
Hs Code.:

(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

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Chemical Property of (18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

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Technology Process of (18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

There total 1 articles about (18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110815-19-5
15-(tert-Butyl-diphenyl-silanyloxy)-15-(3-vinyl-oxiranyl)-pentadecanoic acid (E)-(1S,2R)-6,6-bis-benzenesulfonyl-1,2-dimethyl-hex-4-enyl ester

: 110815-20-8
(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

Guidance literature:: With n-butyllithium; palladium diacetate; triisopropyl phosphite; Product distribution; further catalysts;
DOI:10.1016/S0040-4039(00)85303-4

Reference yield:

: 110815-20-8
(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

: 110815-23-1
(17E,19E,21E,23E)-(25R,26S)-16-(tert-Butyl-diphenyl-silanyloxy)-25,26-dimethyl-oxacyclohexacosa-17,19,21,23-tetraen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) Na(Hg) / 1.) DMAP / 1.) pyridine, room temp., 2.) THF, methanol, AcOH, 0 grad C

2: n-BuLi, Et₃N / Pd(OAc)2, dppb / toluene / 4.5 h / Heating

With n-butyllithium; sodium amalgam; triethylamine; dmap; palladium diacetate; 1,4-di(diphenylphosphino)-butane; In toluene;
DOI:10.1016/S0040-4039(00)85303-4

Reference yield:

: 110815-20-8
(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-25,26-dimethyl-oxacyclohexacosa-18,22-dien-2-one

: 110815-21-9
(18E,22E)-(25R,26S)-21,21-Bis-benzenesulfonyl-16-(tert-butyl-diphenyl-silanyloxy)-25,26-dimethyl-oxacyclohexacosa-18,22-diene-2,17-dione

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)85303-4