Technology Process of (-)(R) Yashabushiketol
There total 10 articles about (-)(R) Yashabushiketol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium phenylseleno(triethyl)borate;
In
ethanol;
for 0.25h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) LDA / 1) THF, -78 deg C, 2) -78 deg C, 2 h
2: 75 percent / ZnCl2, DIBAL / tetrahydrofuran / 2 h / -78 °C
3: 96 percent / TMSCl, Zn / tetrahydrofuran / 0 - 20 °C
4: 1) trimethyloxonium tetrafluoroborate, 2) K2CO3 / 1) CH2Cl2, 2) H2O
5: 1) n-BuLi / 2) THF, -40 deg C
6: 87 percent
7: 1) methyl iodide, CaCO3, 2) camphorsulfonic acid / 1) MeCN, H2O, 2) THF, MeOH
With
n-butyllithium; chloro-trimethyl-silane; camphor-10-sulfonic acid; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; zinc(II) chloride; zinc; lithium diisopropyl amide; methyl iodide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)91579-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / ZnCl2, DIBAL / tetrahydrofuran / 2 h / -78 °C
2: 96 percent / TMSCl, Zn / tetrahydrofuran / 0 - 20 °C
3: 1) trimethyloxonium tetrafluoroborate, 2) K2CO3 / 1) CH2Cl2, 2) H2O
4: 1) n-BuLi / 2) THF, -40 deg C
5: 87 percent
6: 1) methyl iodide, CaCO3, 2) camphorsulfonic acid / 1) MeCN, H2O, 2) THF, MeOH
With
n-butyllithium; chloro-trimethyl-silane; camphor-10-sulfonic acid; trimethoxonium tetrafluoroborate; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; zinc(II) chloride; zinc; methyl iodide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(00)91579-X
