[(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone

Base Information

• Chemical Name: [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone
• CAS No.: 1313611-27-6
• Molecular Formula: C₃₈H₄₈Cl₂N₄O₄S
• Molecular Weight: 727.796

Synonyms:

Chemical Property of [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Useful:

Technology Process of [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone

There total 2 articles about [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-(methylsulfonyl)propyl]-piperazine dihydrochloride + rac-(4S*,5R*)-4,5-bis(4-chlorophenyl)-2-(4-(tert-butyl)-2-ethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl chloride → (4S,5R)-1-[4-[[4,5-bis(4-chlorophenyl)-2-[4-(tert-butyl)-2-ethoxy-phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]]-carbonyl]-4-[3-(methylsulfonyl)propyl]-piperazine (939981-39-2) + [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone (1313611-27-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 7h; Overall yield = 61 mg;

DOI:10.1021/ml400062c

Reference yield:

rac-(4S*,5R*)-4,5-bis(4-chlorophenyl)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole → (4S,5R)-1-[4-[[4,5-bis(4-chlorophenyl)-2-[4-(tert-butyl)-2-ethoxy-phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]]-carbonyl]-4-[3-(methylsulfonyl)propyl]-piperazine (939981-39-2) + [(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazol-1-yl][4-(3-methanesulfonylpropyl)piperazin-1-yl]methanone (1313611-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

2: triethylamine / dichloromethane / 7 h / 0 °C

With triethylamine; In dichloromethane; toluene;

DOI:10.1021/ml400062c

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