Technology Process of [2-(tert-Butyl-dimethyl-silanyloxy)-3-fluoro-6-methoxy-4,5-dimethyl-phenyl]-acetaldehyde
There total 7 articles about [2-(tert-Butyl-dimethyl-silanyloxy)-3-fluoro-6-methoxy-4,5-dimethyl-phenyl]-acetaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 15 percent / N-fluoropyridinium pyridine heptafluorodiborate / acetonitrile / 288 h
2: 96 percent / tetrabutylammonium tribromide / CH2Cl2; methanol / 6 h / 0 °C
3: 100 percent / pyridine / 1 h
4: 43 percent / Pd(PPh3)4 / toluene / 60 h / 90 °C
5: 91 percent / sat. aq. Na2CO3 / methanol / 4 h / 50 °C
6: imidazole / dimethylformamide
7: 1.) pyridine, ozonized O2, 2.) Me3S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, RT, overnight
With
pyridine; 1H-imidazole; ozone-containing oxygen; tetrakis(triphenylphosphine) palladium(0); trimethylsulfonium; N-fluoropyridinium pyridine heptafluorodiborate; tetra-N-butylammonium tribromide; sodium carbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm9603633
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 81 percent / AcOH, conc. HCl / 0.67 h / Heating
2: 15 percent / N-fluoropyridinium pyridine heptafluorodiborate / acetonitrile / 288 h
3: 96 percent / tetrabutylammonium tribromide / CH2Cl2; methanol / 6 h / 0 °C
4: 100 percent / pyridine / 1 h
5: 43 percent / Pd(PPh3)4 / toluene / 60 h / 90 °C
6: 91 percent / sat. aq. Na2CO3 / methanol / 4 h / 50 °C
7: imidazole / dimethylformamide
8: 1.) pyridine, ozonized O2, 2.) Me3S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, RT, overnight
With
pyridine; 1H-imidazole; hydrogenchloride; ozone-containing oxygen; tetrakis(triphenylphosphine) palladium(0); trimethylsulfonium; N-fluoropyridinium pyridine heptafluorodiborate; tetra-N-butylammonium tribromide; sodium carbonate; acetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm9603633
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / tetrabutylammonium tribromide / CH2Cl2; methanol / 6 h / 0 °C
2: 100 percent / pyridine / 1 h
3: 43 percent / Pd(PPh3)4 / toluene / 60 h / 90 °C
4: 91 percent / sat. aq. Na2CO3 / methanol / 4 h / 50 °C
5: imidazole / dimethylformamide
6: 1.) pyridine, ozonized O2, 2.) Me3S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, RT, overnight
With
pyridine; 1H-imidazole; ozone-containing oxygen; tetrakis(triphenylphosphine) palladium(0); trimethylsulfonium; tetra-N-butylammonium tribromide; sodium carbonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9603633
