(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

Base Information

Chemical Name:(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid
CAS No.:94131-56-3
Molecular Formula:C₂₈H₄₈N₆O₁₂S₂
Molecular Weight:724.854
Hs Code.:

(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

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Chemical Property of (S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

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Technology Process of (S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

There total 7 articles about (S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 87141-27-3
N-benzyloxycarbonyl-1-(p-nitrobenzyl)-δ-(L-α-aminoadipyl)-S-benzyl-L-cysteinyl-D-valine, benzhydryl ester

: 69644-78-6,94131-56-3
(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

: 21566-74-5,93133-50-7,141116-68-9,32467-88-2
(L-α-amino-δ-adipyl)-L-cysteinyl-D-valine

Guidance literature:: With ammonia; sodium;
DOI:10.1039/P19830000941

Reference yield:

: 24325-14-2
(2S)-2-[(phenylmethoxy)carbonyl]aminoadipic acid

: 69644-78-6,94131-56-3
(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / Et₃N / dimethylformamide / 0 deg C -> room temperature, overnight

2: 64 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodi-imide / ethyl acetate

3: 98 percent / 0.2M HCl / nitromethane / 5 h / Ambient temperature

4: 71 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodi-imide / ethyl acetate

5: 1.) Na, liquid NH₃, 2.) air / 2.) pH 8, 2 h

With hydrogenchloride; air; ammonia; sodium; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In nitromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/P19830000941

Reference yield:

: 61852-70-8
D-valine, benzhydryl ester

: 69644-78-6,94131-56-3
(S)-2-Amino-5-[(R)-2-[(R)-2-(5-amino-5-carboxy-pentanoylamino)-2-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethyldisulfanyl]-1-((R)-1-carboxy-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodi-imide / ethyl acetate

2: 1.) Na, liquid NH₃, 2.) air / 2.) pH 8, 2 h

With air; ammonia; sodium; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In ethyl acetate;
DOI:10.1039/P19830000941