γ-t-butyl glutamylhistidylphenylalanylarginine diacetate

Base Information

• Chemical Name: γ-t-butyl glutamylhistidylphenylalanylarginine diacetate
• CAS No.: 75816-32-9
• Molecular Formula: 2C₂H₄O₂*C₃₀H₄₅N₉O₇
• Molecular Weight: 763.849
• Mol file: 75816-32-9.mol

Synonyms:

Chemical Property of γ-t-butyl glutamylhistidylphenylalanylarginine diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of γ-t-butyl glutamylhistidylphenylalanylarginine diacetate

There total 3 articles about γ-t-butyl glutamylhistidylphenylalanylarginine diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-γ-t-butyl-glutamylhistidylphenylalanyl-Nω-nitroarginine methyl ester (75816-29-4) → γ-t-butyl glutamylhistidylphenylalanylarginine diacetate (75816-32-9)

Guidance literature:

With sodium hydroxide; hydrogen; palladium on activated charcoal; rhodium on carbon nanotubes; Yield given. Multistep reaction; 1.) methanol, room temperature, 1 h, 2.) methanol-acetic acid, room temperature, 65 h;

DOI:10.1039/P19800001928

Reference yield:

H-Phe-Arg(NO2)-OMe*HCl (75816-30-7) → γ-t-butyl glutamylhistidylphenylalanylarginine diacetate (75816-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 5m-HCl, isopentyl nitrite, 2.) triethylamine / 1.) dimethylformamide, -7 deg C, 7 min, 2.) 4 deg C, 60 h

2: 1.) m-NaOH, 2.) hydrogen / 2.) 10percent palladium on charcoal, 5percent rhodium on charcoal / 1.) methanol, room temperature, 1 h, 2.) methanol-acetic acid, room temperature, 65 h

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; isopentyl nitrite; palladium on activated charcoal; rhodium on carbon nanotubes;

DOI:10.1039/P19800001928

Reference yield:

N-Z-γ-tert-butylglutamyl-histidine hydrazide (3979-08-6) → γ-t-butyl glutamylhistidylphenylalanylarginine diacetate (75816-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 5m-HCl, isopentyl nitrite, 2.) triethylamine / 1.) dimethylformamide, -7 deg C, 7 min, 2.) 4 deg C, 60 h

2: 1.) m-NaOH, 2.) hydrogen / 2.) 10percent palladium on charcoal, 5percent rhodium on charcoal / 1.) methanol, room temperature, 1 h, 2.) methanol-acetic acid, room temperature, 65 h

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; isopentyl nitrite; palladium on activated charcoal; rhodium on carbon nanotubes;

DOI:10.1039/P19800001928

upstream raw materials:

N-benzyloxycarbonyl-γ-t-butyl-glutamylhistidylphenylalanyl-N^ω-nitroarginine methyl ester

H-Phe-Arg(NO₂)-OMe*HCl

N-Z-γ-tert-butylglutamyl-histidine hydrazide

Downstream raw materials:

N-t-butoxycarbonylseryltyrosylserylmethionyl-γ-t-butyl-glutamylhistidylphenylalanylarginine tosylate