2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester
• CAS No.: 65276-98-4
• Molecular Formula: C₂₂H₂₁N₃O₅S
• Molecular Weight: 439.492
• Mol file: 65276-98-4.mol

Synonyms:

Chemical Property of 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester

There total 2 articles about 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2c-azido-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester → 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester (65276-98-4,65276-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (NH₄)2S / methanol

2: MgSO₄ / benzene

With diammonium sulfide; magnesium sulfate; In methanol; benzene;

DOI:10.1021/jo00402a011

Reference yield:

4-nitrobenzaldehdye (555-16-8) + 2c-amino-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester (65276-96-2,65276-97-3) → 2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester (65276-98-4,65276-99-5)

Guidance literature:

With magnesium sulfate; In benzene;

DOI:10.1021/jo00402a011

Reference yield:

2c-(4-nitro-benzylideneamino)-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester (65276-98-4,65276-99-5) → 1-oxo-2t-(2-phenyl-acetylamino)-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: (i) iPr₂NEt, THF, (ii) 2,4-dinitro-phenylhydrazine, TsOH, CHCl₃, (iii) /BRN= 607585/, Et₃N, CH₂Cl₂

2: CF₃CO₂H, NaHCO₃

With sodium hydrogencarbonate; trifluoroacetic acid;

DOI:10.1021/jo00402a011

upstream raw materials:

4-nitrobenzaldehdye

2c-amino-1-oxo-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester

Downstream raw materials:

1-oxo-2t-(2-phenyl-acetylamino)-(2ar)-2,2a-dihydro-1H,4H-azeto[2,1-b]benzo[d][1,3]thiazine-7-carboxylic acid tert-butyl ester