N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Base Information

Chemical Name:N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide
CAS No.:2183470-12-2
Molecular Formula:C₁₈H₁₂ClF₂N₅O₃S
Molecular Weight:451.841
Hs Code.:

Synonyms:

Suppliers and Price of N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide
25mg
$ 1540.00

ChemScene
GCN2iB 99.81%
100mg
$ 2100.00

ChemScene
GCN2iB 99.81%
50mg
$ 1400.00

ChemScene
GCN2iB 99.81%
25mg
$ 900.00

ChemScene
GCN2iB 99.81%
10mg
$ 450.00

ChemScene
GCN2iB 99.81%
5mg
$ 250.00

Total 9 raw suppliers

Chemical Property of N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Chemical Property:

Boiling Point:662.6±65.0 °C(Predicted)
Density:1.63±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide is an intermediate used in the preparation of heterocyclic compounds as GCN2 inhibitors.

Technology Process of N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

There total 10 articles about N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide acetic acid salt

: 2183470-12-2
N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Guidance literature:: With water; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 886373-70-2
3-amino-5-chloro-2-methoxypyridine

: 2183470-12-2
N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-Amyl nitrite / acetonitrile / 0.83 h / 80 °C

2.1: N-chloro-succinimide; acetic acid / water / 10 - 35 °C

3.1: pyridine / 10 - 35 °C

4.1: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; caesium carbonate / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

4.2: 50 °C

5.1: sodium hydrogencarbonate; water / tetrahydrofuran; ethyl acetate

With pyridine; N-chloro-succinimide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; n-Amyl nitrite; water; sodium hydrogencarbonate; caesium carbonate; acetic acid; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

: 3-(benzylsulfanyl)-5-chloro-2-methoxypyridine

: 2183470-12-2
N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide; acetic acid / water / 10 - 35 °C

2.1: pyridine / 10 - 35 °C

3.1: (bis(tricyclohexyl)phosphine)palladium(II) dichloride; caesium carbonate / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

3.2: 50 °C

4.1: sodium hydrogencarbonate; water / tetrahydrofuran; ethyl acetate

With pyridine; N-chloro-succinimide; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; water; sodium hydrogencarbonate; caesium carbonate; acetic acid; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate;