Technology Process of 1,8-bis[5-{(2,4,6-tri-t-butylphenyl)phosphinoethynyl}-2-thienyl]octane
There total 5 articles about 1,8-bis[5-{(2,4,6-tri-t-butylphenyl)phosphinoethynyl}-2-thienyl]octane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 73 percent / N-iodosuccinimide; acetic acid / CHCl3 / 3 h / 20 °C
2.1: 98 percent / CuI; PPh3; Et3N / Pd(OAc)2 / dimethylformamide / 0.67 h / 80 °C
3.1: 97 percent / aq. KOH / tetrahydrofuran / 2 h / 20 °C
4.1: ethylmagnesium bromide / tetrahydrofuran / 0.17 h / 0 °C
4.2: 388 mg / tetrahydrofuran / 2 h / 20 °C
With
potassium hydroxide; N-iodo-succinimide; copper(l) iodide; ethylmagnesium bromide; acetic acid; triethylamine; triphenylphosphine;
palladium diacetate;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.08.108
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 98 percent / CuI; PPh3; Et3N / Pd(OAc)2 / dimethylformamide / 0.67 h / 80 °C
2.1: 97 percent / aq. KOH / tetrahydrofuran / 2 h / 20 °C
3.1: ethylmagnesium bromide / tetrahydrofuran / 0.17 h / 0 °C
3.2: 388 mg / tetrahydrofuran / 2 h / 20 °C
With
potassium hydroxide; copper(l) iodide; ethylmagnesium bromide; triethylamine; triphenylphosphine;
palladium diacetate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.08.108
- Guidance literature:
-
C20H22S2;
With
ethylmagnesium bromide;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
(2,4,6-tri-tert-butyl)phenylmonochlorophosphane;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Further stages.;
DOI:10.1016/j.tetlet.2004.08.108
