trans-L-N-phenyl-4-methoxyproline

Base Information

• Chemical Name: trans-L-N-phenyl-4-methoxyproline
• CAS No.: 951329-04-7
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Mol file: 951329-04-7.mol

Synonyms:

Chemical Property of trans-L-N-phenyl-4-methoxyproline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-L-N-phenyl-4-methoxyproline

There total 1 articles about trans-L-N-phenyl-4-methoxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromobenzene (108-86-1,52753-63-6) + (2S,4R)-4-methoxypyrrolidine-2-carboxylic acid (75176-09-9) → trans-L-N-phenyl-4-methoxyproline (951329-04-7)

Guidance literature:

DOI:10.1016/j.bmcl.2015.10.031

Reference yield:

N-(tert-butyloxycarbonyl)-S-methylisothiourea (173998-77-1) + trans-L-N-phenyl-4-methoxyproline (951329-04-7) → C19H27N3O4S

Guidance literature:

With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2015.10.031

Reference yield:

trans-L-N-phenyl-4-methoxyproline (951329-04-7) → C27H33Cl2N5O5

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;

DOI:10.1016/j.bmcl.2015.10.031

upstream raw materials:

bromobenzene

(2S,4R)-4-methoxypyrrolidine-2-carboxylic acid