trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole

Base Information

• Chemical Name: trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole
• CAS No.: 103384-06-1
• Molecular Formula: C₂₇H₂₅F₃N₂O
• Molecular Weight: 450.504
• Mol file: 103384-06-1.mol

Synonyms:

Chemical Property of trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole

There total 2 articles about trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-ol (69623-05-8) → trans-(+/-)-8-fluoro-5-(4-fluorophenyl)-2-<4-(4-fluorophenyl)-4-oxobutyl>-2,3,4,4a,5,9b-hexahydro-1H-pyrido<4,3b>indole (103384-06-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Multistep reaction; 1.) CH₂Cl₂, -75 deg C, 20 min, 2.) CH₂Cl₂, RT, 45 min;

DOI:10.1021/jm00160a050

Reference yield:

→ 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one (103384-06-1)

Guidance literature:

Indol-Der., CrO3;

upstream raw materials:

4-[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-ol