C₃₉H₄₉N₄O₁₁PSi

Base Information

Chemical Name:C₃₉H₄₉N₄O₁₁PSi
CAS No.:1360614-04-5
Molecular Formula:C₃₉H₄₉N₄O₁₁PSi
Molecular Weight:808.898
Hs Code.:

C<sub>39</sub>H<sub>49</sub>N<sub>4</sub>O<sub>11</sub>PSi

Synonyms:

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Chemical Property of C₃₉H₄₉N₄O₁₁PSi

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Technology Process of C₃₉H₄₉N₄O₁₁PSi

There total 8 articles about C₃₉H₄₉N₄O₁₁PSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360614-00-1
ethyl [(5'S)-5'-C-(3-bromopropyl)-3'-O-(tert-butyldiphenylsilyloxy)thymidine-5'-O-yl][(5'-O-dimethoxytrityl)thymidine-3'O-yl]phosphite

: 1360614-03-4
C₃₉H₄₉N₄O₁₁PSi

: 1360614-04-5
C₃₉H₄₉N₄O₁₁PSi

Guidance literature:: ethyl [(5'S)-5'-C-(3-bromopropyl)-3'-O-(tert-butyldiphenylsilyloxy)thymidine-5'-O-yl][(5'-O-dimethoxytrityl)thymidine-3'O-yl]phosphite; With lithium bromide; In acetonitrile; at 90 ℃; for 4h; Inert atmosphere; Microwave irradiation;

With trifluoroacetic acid; In dichloromethane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101061

Reference yield:

: 244035-21-0
5'(S)-C-allyl-3'-O-(tert-butyldiphenylsilyl)thymidine

: 1360614-04-5
C₃₉H₄₉N₄O₁₁PSi

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 3 h / 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: pyridine / chloroform / 16 h / 0 - 20 °C / Inert atmosphere

4.1: lithium bromide / N,N-dimethyl-formamide; acetone / 0.75 h / Inert atmosphere; Reflux

5.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

6.1: 5-ethylthiotetrazole / acetonitrile / 0.75 h / 20 °C / Inert atmosphere

7.1: lithium bromide / acetonitrile / 4 h / 90 °C / Inert atmosphere; Microwave irradiation

7.2: Inert atmosphere

With pyridine; dimethylsulfide borane complex; 5-ethylthiotetrazole; toluene-4-sulfonic acid; lithium bromide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile; 7.1: Arbuzov reaction;
DOI:10.1002/ejoc.201101061

Reference yield:

: 1360613-98-4
(5'S)-C-(bromopropyl)-3'-O-(tert-butyldiphenylsilyl)-5'-O-(trimethylsilyl)thymidine

: 1360614-04-5
C₃₉H₄₉N₄O₁₁PSi

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

2.1: 5-ethylthiotetrazole / acetonitrile / 0.75 h / 20 °C / Inert atmosphere

3.1: lithium bromide / acetonitrile / 4 h / 90 °C / Inert atmosphere; Microwave irradiation

3.2: Inert atmosphere

With 5-ethylthiotetrazole; toluene-4-sulfonic acid; lithium bromide; In methanol; acetonitrile; 3.1: Arbuzov reaction;
DOI:10.1002/ejoc.201101061