N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

Base Information

Chemical Name:N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide
CAS No.:917231-35-7
Molecular Formula:C₁₇H₁₆ClN₅OS
Molecular Weight:373.866
Hs Code.:

Synonyms:

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Chemical Property of N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

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Technology Process of N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

There total 7 articles about N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28733-43-9
5-bromonicotinamide

: 917231-35-7
N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / N,N-dimethyl acetamide

2: hydrogenchloride; water

3: tert.-butylnitrite; copper dichloride / dimethyl sulfoxide

4: sodium hydride / dimethyl sulfoxide

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

6: trifluoroacetic acid

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium acetate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; In N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Heck-type reaction;
DOI:10.1016/j.bmcl.2012.01.120

Reference yield:

: 917231-31-3
5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinic acid

: 917231-35-7
N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trifluoroacetic acid

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.120

Reference yield:

: C₉H₈N₄OS*ClH

: 917231-35-7
N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: tert.-butylnitrite; copper dichloride / dimethyl sulfoxide

2: sodium hydride / dimethyl sulfoxide

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: trifluoroacetic acid

With tert.-butylnitrite; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper dichloride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.120