N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

Base Information

Chemical Name:N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide
CAS No.:831234-94-7
Molecular Formula:C₂₀H₁₈F₃N₅O₄S
Molecular Weight:481.455
Hs Code.:

N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

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Chemical Property of N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

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Technology Process of N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

There total 2 articles about N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 347319-41-9
C₁₁H₁₁N₃OS

: methyl 2-(2-oxopyrrolidin-1-yl)acetylimino-3,3,3-trifluoropropionate

: 831234-94-7
N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

Guidance literature:: C₁₁H₁₁N₃OS; methyl 2-(2-oxopyrrolidin-1-yl)acetylimino-3,3,3-trifluoropropionate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With triethylamine; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 2h;
DOI:10.1007/s11172-010-0075-6

Reference yield:

: 7491-74-9
2-oxo-1-pyrrolidine acetamide

: 831234-94-7
N-{4,6-dioxo-1-(3-methylphenyl)-2-thioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-(2-oxopyrrolidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h

2.1: N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 2 h / 90 - 100 °C

With pyridine; In N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0075-6