6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride

Base Information

• Chemical Name: 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride
• CAS No.: 1024589-94-3
• Molecular Formula: C₁₃H₉Cl₂NO
• Molecular Weight: 266.127
• Mol file: 1024589-94-3.mol

Synonyms:

Chemical Property of 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride

There total 1 articles about 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid (928166-93-2) → 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride (1024589-94-3)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

DOI:10.1021/jm100556b

Reference yield: 20.0%

1,1-dimethylethyl 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazinecarboxylate (868542-84-1) + 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride (1024589-94-3) → N'-(5-bromo-2-cyano-4-pyrimidinyl)-6-[4-(chloromethyl)phenyl]-N'-(2-methylpropyl)-3-pyridinecarbohydrazide (928166-94-3)

Guidance literature:

1,1-dimethylethyl 2-(5-bromo-2-cyano-4-pyrimidinyl)-2-(2-methylpropyl)hydrazinecarboxylate; 6-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 20.5h;

With trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/jm100556b

upstream raw materials:

6-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid

Downstream raw materials:

N'-(5-bromo-2-cyano-4-pyrimidinyl)-6-[4-(chloromethyl)phenyl]-N'-(2-methylpropyl)-3-pyridinecarbohydrazide

Refernces