2'-formylbiphenyl-2-acetic acid

Base Information

• Chemical Name: 2'-formylbiphenyl-2-acetic acid
• CAS No.: 126863-81-8
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.258
• Mol file: 126863-81-8.mol

Synonyms:

Chemical Property of 2'-formylbiphenyl-2-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-formylbiphenyl-2-acetic acid

There total 4 articles about 2'-formylbiphenyl-2-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2'-(1,2-dihydroxyethyl)biphenyl-2-acetic acid (126863-80-7) → 2'-formylbiphenyl-2-acetic acid (126863-81-8)

Guidance literature:

With periodic acid; In 1,4-dioxane; water; for 48h; Ambient temperature;

Reference yield:

α,α'-bis(diazo)2,2'-biacetophenone (36784-68-6) → 2'-formylbiphenyl-2-acetic acid (126863-81-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) BF₃-Et₂, 2.) NH₄Cl / 1.) a.) nitromethane, -10 deg C, b.) 5 deg C, 30 min, 2.) H₂O

2: 88 percent / sodium borohydride / dioxane; H₂O / 1.) room temp., 24 h, 2.) 50 deg C, 1 h

3: 87 percent / periodic acid / dioxane; H₂O / 48 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; ammonium chloride; periodic acid; In 1,4-dioxane; water;

Reference yield:

2'-(α-hydroxyacetyl) biphenyl-2-acetic acid lactone (126863-78-3) → 2'-formylbiphenyl-2-acetic acid (126863-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / sodium borohydride / dioxane; H₂O / 1.) room temp., 24 h, 2.) 50 deg C, 1 h

2: 87 percent / periodic acid / dioxane; H₂O / 48 h / Ambient temperature

With sodium tetrahydroborate; periodic acid; In 1,4-dioxane; water;

upstream raw materials:

2'-(1,2-dihydroxyethyl)biphenyl-2-acetic acid

α,α'-bis(diazo)2,2'-biacetophenone

2'-(α-hydroxyacetyl) biphenyl-2-acetic acid lactone

2'-(α-hydroxyacetyl)biphenyl-2-acetic acid

Downstream raw materials:

2'-carboxybiphenyl-2-acetic acid